I use the Windows "High Contrast Black" theme to make all the backgrounds black with white text - it's much easier on my eyes. With the "High Contrast Black" theme Perforce's P4V GUI interface, like many Windows programs, shows white text on a white background, which is not all that helpful.
I contacted Perforce about the issue and got a very fast response with a work around.
If you add a blank file named "p4vstyle.qss" to the directory "c:\program files\perforce\P4VResources", P4V will use the local Windows theme on next startup.
Now my retinas are happy with the cool soothing black background. Thanks Perforce.